There are two interconnected lines of research in the Van Remmen laboratory. The first is the study of how oxidative stress and mitochondrial function modulate age-related loss of skeletal muscle mass and function (sarcopenia) and neuromuscular degeneration (Amyotrophic Lateral Sclerosis (ALS)). The second is the role of mitochondrial function in aging and metabolism. Our research uses mouse models of altered oxidative stress and mitochondrial function to probe these pathways. We utilize a number of experimental approaches from in vivo assessment of animal behavior, motor function, neuronal and muscle function to approaches in cell culture or in isolated mitochondria. At the biochemical level, we interrogate pathways involved in aging and disease using molecular approaches to measure changes in mRNA and proteins. Finally, the Van Remmen laboratory is also a Core facility in the Nathan Shock Center for Excellence in the Biology of Aging. In conjunction with the Szweda laboratory, the Core offers sensitive and reproducible measurement of specific types of oxidative damage to cellular components and changes in redox markers.
|Van Remmen Lab
Aging & Metabolism Research Program
Oklahoma Medical Research Foundation
825 NE 13th Street
Oklahoma City, Oklahoma 73104
Lab Phone: (405)-271-2653
Office Phone: (405)-271-2520